Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 15, Pages 7181-7189Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am401523y
Keywords
graphene oxide; doxorubicin; dextran; hematin; drug resistance
Funding
- National Basic Research Program of China (973 Programs) [2009CB930200, 2011CB933402]
- National Natural Science Foundation of China [21073117, 21004039, 21071094]
- Research Foundation for The Excellent Youth Scholars of Higher Education of Shanghai
- Scientific Research Foundation for the Returned Oversears Chinese Scholars, State Education Ministry, and Shanghai Leading Academic Disciplines [S30109]
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A nanohybrid based on nanoscale graphene oxide (NGO) and dextran has been designed and employed for effectively killing drug-resistant MCF-7/ADR cells. This graphene-based nanohybrid was readily prepared through pi-pi interaction of NGO and hematin-terminated dextran (HDex), being denoted as NGO-HDex. It revealed an improved stability in physiological conditions as compared to native NGO. Besides, NGO-HDex could efficiently load doxorubicin (DOX), an anticancer drug, with drug loading capacity of 3.4 mg/mg NGO and liberate the drug with a pH-dependent profile. Cell viability assay indicated that the NGO-HDex displayed lower cytotoxicity against MCF-7/ADR cells as compared to native NGO. DOX-loaded NGO-HDex, however, revealed more efficient killing effect in the cells than free DOX because the nanohybrid caused a higher amount of DOX accumulated in the cells. The results of this study highlight that the NGO-HDex has high potential for killing drug-resistant cancer cells.
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