Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 21, Pages 10510-10519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am402070k
Keywords
nanopillar; nanorod; focal adhesion; nanowire spacing; nanotechnology; fluorescence; SEM; live cell imaging
Funding
- Danish Agency for Science Technology and Innovation (The Danish Council for Strategic Research CLIPS and ANaCell projects)
- Danish Natural Science Research Council [FTP 11-116984]
- UNIK Synthetic Biology
- Danish Ministry for Science, Technology and Innovation
- Region Alsace
- La Ligue contre le cancer CCIR-FE
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Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery and electrical- and fluorescence-based platforms in the development of biosensors. It is conceivable that NW-based biosensors can be optimized through increased understanding of how the nanotopography influences the interfaced biological material. Using state-of-the-art homogenous NW arrays allow for a systematic investigation of how the broad range of NW densities used by the community influences cells. Here it is demonstrated that indium arsenide NW arrays provide a cell-promoting surface, which affects both cell division and focal adhesion up-regulation. Furthermore, a systematic variation in NW spacing affects both the detailed cell morphology and adhesion properties, where the latter can be predicted based on changes in free-energy states using the proposed theoretical model. As the NW density influences cellular parameters, such as cell size and adhesion tightness, it will be important to take NW density into consideration in the continued development of NW-based platforms for cellular applications, such as molecule delivery and electrical measurements.
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