Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 9, Pages 3599-3606Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am303248p
Keywords
mesoporous material; thin film; zirconia; 3D pore structure; glucose oxidase; electrochemical glucose sensor
Funding
- Basic Science Research Program [NRF-20090081018, NRF-2011-0006268]
- Priority Research Center Program [NRF-2010-0029698]
- Agency for Defense Development through Chemical and Biological Defense Research Center
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Mesoporous zirconia thin films (MZFs) were synthesized using zirconium hydroxide sol particles and a structure directing agent, Pluronic F127 (PEO106PPO70PEO106, EO = ethylene oxide, PO = propylene oxide). By controlling the F127/Zr ratio, we obtained two distinct MZFs with one in the Fmmm structure and the other in the P6(3)/mmc structure. The pore structures of these films were characterized by low-angle X-ray diffraction, grazing incidence small-angle X-ray scattering, electron microscopy, and N-2 sorption measurement. The Fmmm structure has interconnected pores and the P6(3)/mmc structure has less accessible pores. The MZFs were functionalized with glucose oxidase (GOx) and were studied for their potentials as an electrochemical sensor for glucose. The GOx-functionalized MZF electrodes show high sensitivity to glucose in a broad range of glucose concentration of 0.025 - 6.8 mM, which can be attributed to their biocompatibility providing a favorable microenvironment for GOx immobilization and to their 3D pore structures with good accessibility of pores.
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