Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 7, Pages 469-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2989
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Funding
- US National Institutes of Health [AI059621, RC1HL099758]
- Leukemia and Lymphoma Society
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The thymus produces self-tolerant functionally competent T cells. This process involves the import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell fate. Expression of T cell-specific genes, including those encoding the T cell receptor (TCR), is followed by positive and negative selection and the eventual export of mature T cells. Significant progress has been made in elucidating the signals that direct progenitor cell trafficking to, within and out of the thymus. These advances are the subject of this Review, with a particular focus on the role of reciprocal cooperative and regulatory interactions between TCR- and chemokine receptor-mediated signalling.
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