Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 10, Pages 4328-4333Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am400535j
Keywords
carboxyfullerene; oxidative stress; chemical structure; cytoprotective capability; C2C12 cell
Funding
- 973 Program [2011CB302100, 2013CB933701]
- National Natural Science Foundation of China [21121063, 31170963, 21127901]
- China Postdoctoral Science Foundation [20110490603]
- NSAF [11076027]
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Satellite muscle cells play an important role in regeneration of skeletal muscle. However, they are particularly vulnerable to oxidative stress. Herein, we address our efforts on the cytoprotective activities of carboxyfullerenes with different cage size (C-60 vs C-70) and adduct number on postmitotic muscle cell (C2C12 cell). The correlation of the structural effect on the cytoprotective capability of carboxyfullerenes was evaluated. We find that quadrimalonic acid C-70 fullerene (QF(70)) exhibits higher capability on protecting cells from oxidative-induced stress among these tested carboxyfullerenes. The accumulation of intracellular superoxide dismutase (SOD) is proposed to play an important role in their diverse antioxidative ability. Moreover, the pretreatment of QF(70) could also obviously enhance the viability of myotubes originated from oxidative-stressed C2C12 cells, which facilitates the future application of carboxyfullerenes in tissue engineering and nanomedicine.
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