Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 8, Pages 3290-3297Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am400338n
Keywords
bacterial cellulose; aminoalkyl groups; antimicrobial; biocompatibility
Funding
- FCT [SFRH/BPD/70119/2010, Rede/1509/RME/2005, REEQ/515/CTM/2005]
- POPH/ESF program
- CICECO [Pest-C/CTM/LA0011/2011]
- University of Basque Country (UPV/EHU) [GIU 10/16]
- Basque Country Government in the frame of SAIOTEK (BIORESBIOPOL) [S-PE11UN015]
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There has been a great deal of interest in the use of nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as bacterial cellulose does not intrinsically present antimicrobial properties, in the present study, antimicrobial bacterial cellulose membranes were obtained by chemical grafting of aminoalkyl groups onto the surface of its nanofibrillar network. This approach intends to mimic intrinsic antimicrobial properties of chitosan. Interestingly, these novel grafted bacterial cellulose membranes (BC-NH2) are simultaneously lethal against S. aureus and E. coli and nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus may be useful for biomedical applications. In addition to these biological properties, the bioactive nanostructured BC-NH2 membranes also present improved mechanical and thermal properties.
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