Journal
NATURE REVIEWS CANCER
Volume 11, Issue 7, Pages 503-511Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3057
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Funding
- US National Institutes of Health [R01CA082328, U01CA141496]
- Prostate Cancer Foundation
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Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.
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