Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 16, Pages 7995-8001Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am402082d
Keywords
mesoporous silica nanoparticle; drug release; tumor-acidity-activate; synergistic chemotherapy
Funding
- National Natural Science Foundation of China [51125014, 51233003]
- Ministry of Science and Technology of China [2011CB606202]
- Fundamental Research Fund for the Central Universities [201120302020007]
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Mesoporous silica nanoparticles (MSNs) have proved to be an effective carrier for controlled drug release and can be fimctionalized easily for use as stimuli-responsive vehicles. Here, a novel intelligent drug-delivery system (DDS), camptothecin (CPT)-loaded and doxorubicin (DOX)-conjugated MSN (CPT@MSN-hyd-DOX), is reported via a facile one-pot preparation for use in synergistic chemotherapy of glioblastoma. DOX was conjugated to MSNs via acid-labile hydrazone bonds, and CPT was loaded in the pores of the MSNs. At pH 6.5 (analogous to the pH in tumor tissues), a fast DOX release was observed that was attributed to the hydrolysis of the hydrazone bonds. In addition, a further burst release of DOX was found at pH 5.0 (analogous to the pH in lyso/endosomes of tumor cells), leading to a strong synergistic effect. In all, CPT and DOX could be delivered simultaneously into tumor cells, and this intelligent DDS has great potential for tumor-trigged drug release for use in the synergistic chemotherapy of tumors.
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