Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 11, Pages 5232-5238Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am401059k
Keywords
phototrigger; magnetic nanoparticles; coumarin; drug delivery; chlorambucil
Funding
- DST (SERB)
- Indian Institute of Technology Kharagpur
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Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of similar to 9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the, cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good, biocompatibility and efficient, photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.
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