Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 4, Issue 4, Pages 1872-1877Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am300198v
Keywords
gold nanorod; stabilization; block copolymer; micelle; encapsulation; CTAB
Funding
- 3M Company
- National Science Foundation (NSF) [DMR-0906567]
- KCC Corporation (Korea)
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0906567] Funding Source: National Science Foundation
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Gold nanorods (GNRs) have the potential to be used as imaging and hyperthermia agents for cancer theranostics. Clinical applications of as-synthesized GNRs (i.e., cetyl trimethylammonium bromide (CTAB)-coated GNRs) are currently limited by their cytotoxicity and insufficient colloidal stability. With an aim to address these problems, we developed a self-assembly processing technique for encapsulating GNRs in poly(ethylene oxide)-poly(n-butyl acrylate) (PEO-PnBA) block copolymer (BCP) micelles. This technique uses simple steps of solvent exchange processes, based on the known principles of block copolymer self-assembly. The resultant BCP-encapsulated GNRs were found to be stable against aggregation under physiological salt conditions for indefinite periods of time, which has rarely previously been achieved by other means of encapsulation.
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