Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 4, Issue 12, Pages 6479-6486Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am301301f
Keywords
iron oxide; bovine serum albumin; ultrasound; magnetic resonance imaging liver
Funding
- National Natural Science Foundation of China [51003078, 81171393, 81271629]
- Nanotechnology Program of Shanghai Science & Technology Committee [11 nm0504500]
- Program for Outstanding Young Teachers in Tongji University
- Fundamental Research Funds for the Central Universities
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Nanoclusters of superparamagnetic iron oxide nanoparticles (SPION) are developed for liver-specific magnetic resonance imaging (MM) by a unique synthesis route. The process is efficient, environmentally benign, and straight forward within five minutes. The clustering effect is triggered in the presence of bovine serum albumin (BSA) aqueous phase under ultrasonication condition. The hydrophobic SPION are densely self-assembled into BSA/SPION hybrid nanoclusters with a uniform size of similar to 86 nm. The as-prepared BSA/SPION hybrid nanoclusters are found to be biocompatible and stable. They exhibit high transverse relaxivity and longitudinal relaxivity in water (r(2) and r(1) values are 600.8 and 4.3 s(-1) per mM of Fe3+, respectively). In vivo T-2-weighted MM shows excellent enhancement in liver with an imaging time-window up to 48 h. In vivo biodistribution study indicates a gradual excretion of the nanoclusters via hepatobiliary (HB) processing. No toxicity is observed in the in vivo and ex vivo experiments. The BSA/SPION hybrid nanoclusters present great potential in MRI as the liver-specific contrast agents (CAs).
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