Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 3, Issue 8, Pages 2885-2894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am2004398
Keywords
titanium; microarc oxidation; dendrimer; antibacterial coatings; mesenchcymal stem cell
Funding
- NSF [CMMI 0802265]
- Welch Foundation [E-1498]
- Alliance for NanoHealth [W81XWH-09-2-0139]
- National Natural Science Foundation of China [50732003, 50803018, U0834003]
- China Scholarship Council
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In this article, we present the first report on the antibacterial activity and cytotoxidty of poly(amidoamine) (PAMAM) dendrimers immobilized on three types of titanium-based substrates with and without calcium phosphate coating. We show that the amino-terminated PAMAM dendrimers modified with various percentages (0-60%) of poly(ethylene glycol) (PEG) strongly adsorbed on the titanium-based substrates. The resultant dendrimer films effectively inhibited the colonization of the Gram-negative bacteria Pseudomonas aeruginosa (strain PAO1) and, to a lesser extent, the Gram-positive bacteria Staphylococcus aureus (SA). The antibacterial activity of the films was maintained even after storage of the samples in PBS for up to 30 days. In addition, the dendrimer films had a low cytotoxicity to human bone mesenchymal stem cells (hMSCs) and did not alter the osteoblast gene expression promoted by the calcium phosphate coating.
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