Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 3, Issue 7, Pages 2479-2486Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am200364e
Keywords
mesoporous silica nanocage; drug delivery; photodynamic therapy; sustained release; cancer therapy; fluorescence imaging
Funding
- National High Technology Research and Development Program of China [2007AA03Z354]
- Ministry of Education of China [IRT0714]
- National Natural Science Foundation of China [20703009]
- Fundamental Research Funds for the Central Universitiey [10JCXK004, 10JCXK006]
- Science and Technology Development Planning of Jilin Province [20100929, 20100320]
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Highly uniform and multifunctional hollow mesoporous silica nanocages that combined excellent properties (good biocompatibility, fluorescence imaging, drug delivery, and dual-mode cancer therapy) in one single system were synthesized. Dye molecules labeled in the nanocages could be used as traceable detectors in fluorescence imaging. A chemotherapeutic drug, doxorubicin (DOX), has been loaded into the nanocages with a high storage capacity due to the large cubic cavities and could be released through the penetrating mesoporous channels in a sustained fashion. Hematoporphyrin molecules were also covalently doped in the nanocages and allowed for photodynamic therapy. More importantly, a cooperative, synergistic therapy combining chemotherapy and photodynamic therapy exhibited high therapeutic efficacy for cancer therapy in vitro.
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