Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 3, Issue 9, Pages 3308-3315Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am2007855
Keywords
magnetic molecularly imprinted polymers; PDE-5 inhibitors; tadalafil; medicines; HPLC-UV
Funding
- National Natural Science Foundation of China [20875048, 21175070]
- Natural Science Foundation of Jiangsu Province [BK2008439]
- University Students' Practice Innovation Training Project Funds of Jiangsu Province [KY109J2010001]
Ask authors/readers for more resources
In this paper, highly selective core-shell molecularly imprinted polymers (MIPs) of tadalafil on the surface of magnetic nanoparticles (MNPs) were prepared. Three widely used functional monomers 2-(trifluoromethyl) acrylic acid (TFMAA), acrylic acid (AA), and methacrylic acid (MAA) were compared theoretically as the candidates for MIP preparation. MIP-coated magnetic nanoparticles (MIP-coated MNPs) showed large adsorption capacity, high recognition ability, and fast binding kinetics for tadalafil. Furthermore, because of the good magnetic properties, MIP-coated MNPs can achieve rapid and efficient separation with an external magnetic field simply. The resulting MIP-coated MNPs were used as dispersive solid-phase extraction (DSPE) materials coupled with HPLC-UV for the selective extraction and detection of tadalafil from medicines (herbal sexual health products). Encouraging results were obtained. The amounts of tadalafil that were detected from the herbal sexual health product was 43.46 nmol g(-1) and the recoveries were in the range of 87.36-90.93% with the RSD <6.55%.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available