Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 3, Issue 11, Pages 4437-4443Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am201101d
Keywords
L-diphenilalanine nanostructures; copper(II) complexes; biomimetic sensors; dopamine
Funding
- Brazilian agency Fundacao de Amparo a Pesquisa do Estado de So Paulo (FAPESP) [08/53576-9]
- Brazilian agency CNPq [474871/2010]
- INCT in Bioanalytics (FAPESP) [08/57805-2]
- INCT in Bioanalytics (CNPq) [573672/2008-3]
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Self-assembled peptide nanostructures are electronically insulating as are most biomaterials derived from natural amino acids. To obtain additional properties and increase the applicability of peptide nanomaterials, some chemical modifications can be performed and materials can be functionalized to form hybrid compounds. In this work, we described the formation of L-diphenylalanine nanotubes (PNTs) with cyclic-tetrameric copper(II) species containing the ligand (4-imidazolyl)-ethylene-2-amino-1-ethylpyridine [Cu-4(apyhist)(4)](4+) in the Nafion membrane on a vitreous carbon electrode surface. This copper complex has been studied as structural and functional models for the active centers of copper containing redox enzymes. Scanning electron microscopy was used to confirm the formation of the nanostructures. The electrochemical properties of the PNT-[Cu-4(apyhist)(4)](4+)/Nafion film on a glassy carbon electrode were characterized using cyclic voltammetry and square-wave voltammetry and showed high electrocatalytic activity toward the oxidation of dopamine (DA). The detection sensitivity was found to be enhanced by the use of copper (II) complex in the PNTs/Nafion films. Under the optimum conditions, the square-wave voltammetry peak height was linearly related to the DA concentration over two concentration intervals, viz., 5.0-40 mu mol L-1 and 40-1000 mu mol L-1. The detection limit was 2.80 mu mol L-1 (S/N = 3), and ascorbic acid did not interfere with the DA detection. These results suggested that this hybrid bioinorganic system provides an attractive advantage for a new type of electrochemical sensors. The detection sensitivity was found to be enhanced by use of PNTs.
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