Journal
IMMUNOBIOLOGY
Volume 220, Issue 8, Pages 1006-1011Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2015.04.004
Keywords
Galectins; Mast cells; Metalloproteinases; Oral cancer; Potentially Malignant Disorders
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Funding
- University of Uberaba (UNIUBE)
- Federal University of Triangulo Mineiro (UFTM)
- FAPEMIG
- CNPq
- CAPES
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Objectives: To evaluate the expression of Galectins (Gal) 1,3 and 9, Metalloproteinase 3 (MMP-3) and mast cell density in oral lesions of patients with potentially malignant disorders (PMD) and oral squamous cell carcinomas (OSCC) by comparison with the controls. Study design: We selected 40 cases of PMD, 40 OSCC and 13 with normal histopathological profile. Immunohistochemistry was performed for Gal-1, Gal-3, Gal-9 and MMP-3. Results: Gal-9 was significantly higher in patients with OSCC than in others groups (p < 0.001). Gal-1 expression was significantly lower in patients with leukoplakia than those with OSCC and controls (p = 0.0001). Gal-3 was significantly lower in patients with OSCC than those with leukoplakia (p = 0.03). MMP-3 was lower in patients with leukoplakia in comparison with the lichen planus group (p = 0.013). Conclusion: The increased expression of Gal-9 may be helpful to differentiate of OSCC from other oral cavity lesions. (C) 2015 Elsevier GmbH. All rights reserved.
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