Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 2, Issue 4, Pages 1009-1018Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am900712e
Keywords
Michael addition; in situ; hydrogel; thermosensitivity
Funding
- National Natural Science Foundation of China [20504024, 20774069]
- Ministry of Education of China [707043]
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To investigate the possibility of in situ thermosensitive hydrogel formation via Michael-type addition reaction, we designed and prepared thiol- and vinyl-modified poly(N-isopropylacrylamide) (PNIPAAm)-based copolymers. When the solutions of these two kinds of PNIPAAm-based copolymers were mixed at physiological temperature (37 C), a physical gelation resulting from the hydrophobic aggregation of PNIPAAm based copolymers and chemical cross-linking between thiol and vinyl functional groups or so-called chemical gelation occurred, resulting in the formation of a three-dimensional hydrogel. Because all the gelations were performed at a high temperature (above LCSTs of the PNIPAAm based copolyrners), these in situ formed hydrogels presented heterogeneous network structures, resulting in an improved thermosensitivity in comparison with the conventional one.
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