Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 2, Issue 8, Pages 2429-2435Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am100435k
Keywords
conjugated polymers; nanoparticles; imaging; drug delivery
Funding
- National Natural Science Foundation of China [20725308, 90913014, TRR61]
- Major Research Plan of China [2006CB932100]
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We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is prepared by electrostatic assembly of cationic conjugated polymer PFO and anionic poly(L-glutamic acid) conjugated with anticancer drug doxorubicin (PFO/PG-Dox). The PFO exhibits good fluorescence quantum yield, photostability, and little cytotoxicity to meet the essential requests for cell imaging. In PFO/PG-Dox nanoparticles, the fluorescence of PFO is highly quenched by Dox by electron transfer mechanism, and thus the PFO is in the fluorescence turn-off state. After PFO/PG-Dox nanoparticles are exposed to carboxypeptidase or are taken up by cancer cells, the poly(L-glutamic acid) is hydrolysed to release the Dox, inducing the activation of PFO fluorescence to turn-on state. This multifunctional nanoparticle system can deliver Dox to targeted cancer cells and monitor the Dox release based on fluorescence turn-on signal of PFO, which concurrently images the cancer cells. The present work opens the door for new functional studies of conjugated polymer in simultaneous imaging and disease therapeutics.
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