Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 2, Issue 4, Pages 952-956Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am100018k
Keywords
electrospinning; nanofiber; antimicrobial efficacy; N-halamine; cellulose acetate
Funding
- National Institutes of Health (NIH) [R01-DE-018707]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE018707] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (CI-BTMP) were prepared and evaluated: the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and CI-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had excellent mammal cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available