Journal
IMMUNITY
Volume 43, Issue 4, Pages 634-645Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2015.09.013
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Funding
- American Cancer Society
- Searle Scholars Program
- Cancer Research Institute
- NIH [AI085034, P30CA008748, AI100874, AI066897, AI068129]
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Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.
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