Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 1, Issue 7, Pages 1474-1481Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am9001293
Keywords
metalloporphyrins; room-temperature phosphorescence; in vivo optical imaging; polymeric nanomicelles; tumor detection
Funding
- National institutes of Health [R01 CA119397, RO1 CA104492]
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We report a formulation of near-infrared (near-IR) phosphorescent polymeric nanomicelles and their use for in vivo high-contrast optical imaging, targeting, and detection of tumors in small animals. Near-IR phosphorescent molecules of Pt(II)-tetraphenyltetranaphthoporphyrin (Pt(TPNP)) were found to maintain their near-IR phosphorescence properties when encapsulated into phospholipid nanomicelles. The prepared phosphorescent micelles are of similar to 100 nm size and are highly stable in aqueous suspensions. A large spectral separation between the Pt(TPNP) absorption, with a peak at similar to 700 nm, and its phosphorescence emission, with a peak at similar to 900 nm, allows a dramatic decrease in the level of background autofluorescence and scattered excitation light in the near-IR spectral range, where the signal from the phosphorescent probe is observed. in vivo animal imaging with subcutaneously xenografted tumor-bearing mice has resulted in high contrast optical images, indicating highly specific accumulation of the phosphorescent micelles into tumors. Using optical imaging with near-IR phosphorescent nanomicelles, detection of smaller, visually undetectable tumors has also been demonstrated.
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