Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 1, Issue 2, Pages 266-269Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am800219r
Keywords
nanowires; calcium phosphate; bisphosphonates; tissue engineering; mesenchymal cells
Funding
- Robert A. Welch Foundation
- National institute of General Medical Sciences/NIH [1ROI GM067610]
Ask authors/readers for more resources
Medicinal surface modification of silicon nanowires (SiNWs) with selected bisphosphonates, such as the known antiosteoporotic drug alendronate is described. In terms of specific assays relevant to orthopedic applications the impact of selected bisphosphonate attachment on a cellular calcification in simulated plasma is reported. To further investigate biocompatibility, proliferation assays of these modified nanowires were carried out using an orthopedically relevant cell line; mesenchymal stem cells derived from mouse stroma. It is found that the identity of the bisphosphonate ligand strongly and sensitively impacts its resultant cytotoxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available