Journal
IMMUNITY
Volume 42, Issue 3, Pages 431-442Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2015.02.013
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Funding
- NIH [5R21CA149476]
- Michigan State University
- National Agenda Project grant from the Korea Research Council of Fundamental Science and Technology, Republic of Korea
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Long-lived memory-like'' NK cells have been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about how the memory-like NK cell pool is formed. Here, we have shown that HCMV-infected individuals have several distinct subsets of memory-like NK cells that are often deficient for multiple transcription factors and signaling proteins, including tyrosine kinase SYK, for which the reduced expression was stable over time and correlated with epigenetic modification of the gene promoter. Deficient expression of these proteins was largely confined to the recently discovered FcRg-deficient NK cells that display enhanced antibody-dependent functional activity. Importantly, FcRg-deficient NK cells exhibited robust preferential expansion in response to virus-infected cells (both HCMV and influenza) in an antibody-dependent manner. These findings suggest that the memory-like NK cell pool is shaped and maintained by a mechanism that involves both epigenetic modification of gene expression and antibody-dependent expansion.
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