Journal
NATURAL PRODUCTS AND BIOPROSPECTING
Volume 1, Issue 1, Pages 48-51Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13659-011-0009-5
Keywords
Swertia kouitchensis; anti-HBV activity; swertiakoulactone; swertiakoside A; swertiakoside B
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Funding
- National Natural Sciences Foundation of China for Distinguished Young Scholar [81025023]
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Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.39) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.12).
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