Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 8, Pages 519-531Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3024
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [5 x 1000]
- European Research Council
- Fondazione Cariverona
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Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. The newly discovered repertoire of effector molecules in the neutrophil armamentarium includes a broad array of cytokines, extracellular traps and effector molecules of the humoral arm of the innate immune system. In addition, neutrophils are involved in the activation, regulation and effector functions of innate and adaptive immune cells. Accordingly, neutrophils have a crucial role in the pathogenesis of a broad range of diseases, including infections caused by intracellular pathogens, autoimmunity, chronic inflammation and cancer.
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