Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 8, Pages 558-U82Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3027
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Funding
- US National Institutes of Health [AI085439, AI072571]
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Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs - do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?
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