Journal
BIOMEDICAL ENGINEERING LETTERS
Volume 1, Issue 3, Pages 163-167Publisher
SPRINGERNATURE
DOI: 10.1007/s13534-011-0025-8
Keywords
Poly(lactic acid); Biodegradation; Copolymerization; Polymer blends; E-beam radiation; Polymer additives
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Funding
- Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A110962]
- Korea Health Promotion Institute [A110962] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Poly(lactic acid) (PLA) is widely used in many different biomedical applications due to its biocompatibility, complete biodegradability, and non-toxic degradation products. However, PLA may be limited in particularly long degradation, which is not always desirable in many biomedical applications. In this short review, we summarized some of the most recent studies on controlling the degradation rate of PLA, employing copolymerization, blending, additives and irradiation. This review discussed the pros and cons of those methods considering their applications to bioabsorbable fixation or drug delivery devices. We also suggested the design parameters for PLA treatment for its wide applicability to biomedical fields.
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