Journal
NATURE REVIEWS CANCER
Volume 11, Issue 8, Pages 541-557Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrc3087
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Funding
- Soft Tissue Sarcoma Program Project [P01 CA047179]
- SPORE in Soft Tissue Sarcoma [P50 CA140146-01]
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Increasingly, human mesenchymal malignancies are being classified by the abnormalities that drive their pathogenesis. Although many of these aberrations are highly prevalent within particular sarcoma subtypes, few are currently targeted therapeutically. Indeed, most subtypes of sarcoma are still treated with traditional therapeutic modalities, and in many cases sarcomas are resistant to adjuvant therapies. In this Review, we discuss the core molecular determinants of sarcomagenesis and emphasize the emerging genomic and functional genetic approaches that, coupled with novel therapeutic strategies, have the potential to transform the care of patients with sarcoma.
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