Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 8, Pages 551-558Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3020
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Funding
- Howard Hughes Medical Institute
- Bill and Melinda Gates Foundation [51731]
- US National Institutes of Health (NIH) [U19AI057229]
- NIH [N01A125456M0D13]
- Emory Center for AIDS research [P30 AI050409]
- American Cancer Society
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Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
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