Simultaneous imaging of haemoglobin oxygenation and blood flow with RGB reflectometry and LASCA during stroke in rats

We demonstrate the simultaneous mapping of haemoglobin oxygenation and blood flow changes of human skin and the exposed cortex in rats by broad-band reflectometry and laser speckle contrast analysis (LASCA). A hard-and software set-up is realized with a high temporal resolution achieved by techniques of multi-and manycore computing. Spatial and temporal resolved changes of haemoglobin oxygenation and blood flow in rats are observed in response to middle cerebral artery occlusion and cortical spreading depression.