4.6 Article

An Additive Selection of Markers to Improve Diagnostic Accuracy Based on a Discriminatory Measure

Journal

ACADEMIC RADIOLOGY
Volume 20, Issue 7, Pages 854-862

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2013.02.009

Keywords

Receiver operating characteristic (ROC); area under the ROC curves (AUC); discriminatory score; Box-Cox transformation

Funding

  1. Intramural NIH HHS [ZIA HD008875-01] Funding Source: Medline

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Rationale and Objectives: The estimation of the area under the receiver operating characteristic (ROC) curve (AUC) often relies on the assumption that the truly positive population tends to have higher marker results than the truly negative population. The authors propose a discriminatory measure to relax such an assumption and apply the measure to identify the appropriate set of markers for combination. Materials and Methods: The proposed measure is based on the maximum of the AUC and 1-AUC. The existing methods are applied to estimate the measure. The subset of markers is selected using a combination method that maximizes a function of the proposed discriminatory score with the number of markers as a penalty in the function. Results: The properties of the estimators for the proposed measure were studied through large-scale simulation studies. The application was illustrated through a real example to identify the set of markers to combine. Conclusion: Simulation results showed excellent small-sample performance of the estimators for the proposed measure. The application in the example yielded a reasonable subset of markers for combination.

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