Journal
IET NANOBIOTECHNOLOGY
Volume 9, Issue 6, Pages 368-374Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-nbt.2014.0075
Keywords
nanoparticles; silver; organic compounds; nanocomposites; nanomedicine; suspensions; coatings; biological tissues; single photon emission computed tomography; liver; blood; cancer; patient treatment; nanofabrication; in vivo evaluation; intravenously administered-naked functionalised silver nanoparticles; water-based suspension; silver nanoparticles; dextran coated AgNP; radiolabelling; in vivo tissue uptake; biodistribution analysis; single-photon emission computed tomography imaging; liver-spleen region; reticuloendothelum system; enhanced blood retention time; liver cancer treatment
Funding
- Higher Education Commission (HEC) of Pakistan
- Physics Department, University of Engineering and Technology Lahore
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Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with Tc-99m was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that Tc-99m-AgNPs and Tc-99m-dextran-AgNPs are mainly accumulated in liver/spleen region but Tc-99m-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.
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