Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 9, Pages 584-596Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3045
Keywords
-
Categories
Funding
- Australian National Health and Medical Research Council
- Cancer Council Western Australia
- Asthma Foundation of Western Australia
- Raine Foundation
- Brightspark Foundation
Ask authors/readers for more resources
Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (UV) radiation exposure and the positive latitude gradients observed for some immune-mediated diseases may therefore reflect the activities of UV-induced vitamin D. Alternatively, other mediators that are induced by UV radiation may be more important for UV-mediated immunomodulation. Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available