Journal
ANATOMY & CELL BIOLOGY
Volume 44, Issue 3, Pages 169-175Publisher
MEDRANG
DOI: 10.5115/acb.2011.44.3.169
Keywords
Clusterin; Apoptosis; Brain
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Funding
- MRC program of the National Research Foundation of Korea [R13-2005-012-01001-1]
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Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
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