Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 9, Pages 597-606Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3049
Keywords
-
Categories
Funding
- US National Institute of Allergy and Infectious Diseases (NIAID) [R21 AI083540-01, T32 AI60573]
Ask authors/readers for more resources
It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer metastasis was first documented. Since then, the field of chemokines and cancer has grown significantly, so it is timely to review the progress, analyse the studies to date and identify future challenges facing this field. Metastasis is the major factor that limits survival in most patients with cancer. Therefore, understanding the molecular mechanisms that control the metastatic behaviour of tumour cells is pivotal for treating cancer successfully. Substantial experimental and clinical evidence supports the conclusion that molecular mechanisms control organ-specific metastasis. One of the most important mechanisms operating in metastasis involves homeostatic chemokines and their receptors. Here, we review this field and propose a model of 'cellular highways' to explain the effects of homeostatic chemokines on cancer cells and how they influence metastasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available