Journal
AAPS PHARMSCITECH
Volume 16, Issue 1, Pages 10-20Publisher
SPRINGER
DOI: 10.1208/s12249-014-0251-3
Keywords
controlled release; drug combination; drug delivery; drug solubilization; polymeric micelles
Categories
Funding
- Global Innovative Research Center program of the National Research Foundation of Korea
- Intramural Research Program (Global RNAi Carrier Initiative) of Korean Institute of Science and Technology
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Drug combinations are common in cancer treatment and are rapidly evolving, moving beyond chemotherapy combinations to combinations of signal transduction inhibitors. For the delivery of drug combinations, i.e., multi-drug delivery, major considerations are synergy, dose regimen (concurrent versus sequential), pharmacokinetics, toxicity, and safety. In this contribution, we review recent research on polymeric micelles for multi-drug delivery in cancer. In concurrent drug delivery, polymeric micelles deliver multi-poorly water-soluble anticancer agents, satisfying strict requirements in solubility, stability, and safety. In sequential drug delivery, polymeric micelles participate in pretreatment strategies that prime solid tumors and enhance the penetration of secondarily administered anticancer agent or nanocarrier. The improved delivery of multiple poorly water-soluble anticancer agents by polymeric micelles via concurrent or sequential regimens offers novel and interesting strategies for drug combinations in cancer treatment.
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