Journal
AAPS PHARMSCITECH
Volume 15, Issue 1, Pages 177-188Publisher
SPRINGER
DOI: 10.1208/s12249-013-0051-1
Keywords
alpha-Cyclodextrin; controlled release; naltrexone hydrochloride; PLGA-PEG-PLGA; supramolecular hydrogel; vitamin B12
Categories
Funding
- Mashhad University of Medical Sciences
Ask authors/readers for more resources
Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic diseases and specific conditions encourage scientists to invent different delivery systems. To this purpose, a supramolecular hydrogel consisting of the tri-block copolymer PLGA-PEG-PLGA and alpha-cyclodextrin was fabricated for the first time and characterised in terms of rheological, morphological, and structural properties. Naltrexone hydrochloride and vitamin B12 were loaded, and their release profiles were determined.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available