Journal
AAPS PHARMSCITECH
Volume 14, Issue 1, Pages 133-140Publisher
SPRINGER
DOI: 10.1208/s12249-012-9904-2
Keywords
liposomes; meloxicam; skin permeation; surfactant; transfersomes
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Funding
- Silpakorn University Research and Development Institute, Graduate School of Silpakorn University
- Thailand Research Funds through the Golden Jubilee Ph.D. Program [PHD/0141/2550]
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The aim of this study is to develop meloxicam (MX)-loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes (i.e., particle size, size distribution, droplet surface charge and morphology), entrapment efficiency, stability of formulations and in vitro skin permeation of MX. The transfersomes displayed a spherical structure. Their size, charge, and entrapment efficiency depended on the composition of cholesterol and cationic surfactants in the formulation. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The penetration-enhancing mechanism of skin permeation by the vesicles prepared in this study may be due to the vesicle adsorption to and/or fusion with the stratum corneum. Our results suggest that cationic transfersomes may be promising dermal delivery carriers of MX.
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