Journal
AAPS PHARMSCITECH
Volume 13, Issue 2, Pages 548-555Publisher
SPRINGER
DOI: 10.1208/s12249-012-9774-7
Keywords
docetaxel anhydrous; FT-IR spectroscopy; nuclear magnetic spectroscopy; p-XRD; thermal analysis; vapor-induced transformations
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Funding
- Aptuit Laurus Pvt. Ltd.
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Vapor-induced transformations of docetaxel anhydrous (form D-A) under ambient conditions have been studied using methanol, ethanol, and water as the solvent media. The online vapor-induced transformations were monitored by powder X-ray diffractometry. New solid forms (solvates/hydrates/anhydrous) of docetaxel anhydrous were obtained in stoichiometric ratios which were characterized completely using powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, and spectroscopic (C-13 solid-state nuclear magnetic spectroscopy, solution H-1 NMR, and Fourier transform infrared) techniques. The new forms namely methanol solvate (D-M), ethanol solvate (D-E), monohydrate (D-MH), trihydrate (D-TH), and anhydrous (DAN-I and DAN-II) were identified through structural analysis.
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