Journal
AAPS JOURNAL
Volume 11, Issue 1, Pages 109-119Publisher
SPRINGER
DOI: 10.1208/s12248-009-9084-5
Keywords
ajulemic acid; cannabinoid; elmiric acid; endocannabinoid; inflammation
Categories
Funding
- National Institutes of Health, Bethesda, MD [DA17969, DA13691, AI 056362]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI056362] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA013691, R21DA017969] Funding Source: NIH RePORTER
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This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol, synthetic analogs such as ajulemic acid and nabilone, the endogenous cannabinoids anandamide and related compounds, namely, the elmiric acids, and finally, noncannabinoid components of Cannabis that show anti-inflammatory action. It is intended to be an update on the topic of the involvement of cannabinoids in the process of inflammation. A possible mechanism for these actions is suggested involving increased production of eicosanoids that promote the resolution of inflammation. This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promote the induction of the inflammatory process.
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