Journal
AAPS JOURNAL
Volume 12, Issue 1, Pages 61-72Publisher
SPRINGER
DOI: 10.1208/s12248-009-9160-x
Keywords
exit time; flow graphs; permanence time; residence time; tracer kinetics; transfer function; turnover time
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In this paper, I show how the concept of compartment evolved from the simple dilution of a substance in a physiological volume to its distribution in a network of interconnected spaces. The differential equations describing the fate of a substance in a living being can be solved, qualitatively and quantitatively, with the help of a number of mathematical techniques. A number of parameters of pharmacokinetic interest can be computed from the experimental data; often, the data available are not sufficient to determine some parameters, but it is possible to determine their range.
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