Journal
WORLD JOURNAL OF DIABETES
Volume 2, Issue 9, Pages 137-148Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v2.i9.137
Keywords
Developmental programming; Metabolic syndrome; Obesity; Type 2 diabetes; Leptin; Animal models; Predictive adaptive responses
Categories
Funding
- Health Research Council of New Zealand
- Marsden Fund of the Royal Society
- Foundation for Research Science and Technology
- National Research Centre for Growth and Development
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Metabolic disease results from a complex interaction of many factors, including genetic, physiological, behavioral and environmental influences. The recent rate at which these diseases have increased suggests that environmental and behavioral influences, rather than genetic causes, are fuelling the present epidemic. In this context, the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual, fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome. Although the mechanisms are yet to be fully elucidated, this programming was generally considered an irreversible change in developmental trajectory. Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity. This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.
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