Journal
ADIPOCYTE
Volume 7, Issue 3, Pages 226-228Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2018.1493901
Keywords
gp130; insulin resistance; glucose tolerance; high fat diet; obesity; fat depot
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Funding
- Gottfried und Julia Bangerter-Rhyner-Stiftung
- Schweizerischer National-fonds zur Forderung der Wissenschaftlichen Forschung [310030-179344]
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High secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Mechanistically, IL-6 induces the release of free fatty acid (FFA) and leptin from adipocytes thereby affecting liver metabolism and pancreatic -cell function, respectively. This commentary further discusses the role of adipocyte-specific IL-6-type cytokine signaling in the regulation of FFA and leptin release. In particular, we outline depot-specific differences in IL-6-induced basal release of the two aforementioned factors. Moreover, we provide evidence that insulin's effect on the release of FFA and leptin is adipose depot-dependent. We conclude that adipose depot-specific targeting of the IL-6 signaling pathway may be a novel approach to blunt obesity-associated metabolic complications.
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