Journal
DIABETES & METABOLISM JOURNAL
Volume 42, Issue 3, Pages 188-195Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2017.0105
Keywords
Diabetes complications; Glycation end products; advanced; Receptor for advanced glycation end products
Categories
Funding
- Korea Healthcare Technology R&D Project, Ministry of Health and Welfare Republic of Korea [HI10C2020]
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In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.
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