Journal
DIABETES & METABOLISM JOURNAL
Volume 42, Issue 2, Pages 164-168Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2018.42.2.164
Keywords
Alginic acid; Catechol; Diabetes mellitus; type 1; Hydrogel; Islets of Langerhans transplantation
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Funding
- faculty research grant of Yonsei University College of Medicine [6-2009-0065]
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Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation. Alginate has been considered to be a reliable biomaterial, as it enhances islet survival and does not hamper hormone secretion. Alginate-catechol (Al-CA) hydrogel was reported to provide high mechanical strength and chemical stability without deformation over a wide range of pH values. In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation.
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