Journal
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 13, Issue 1, Pages 12-23Publisher
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2017.08.004
Keywords
Flavonoid; Activity; Structure; Pharmacokinetics; Bioavailability
Categories
Funding
- National Natural Science Foundation of China [81473324]
- National Key Scientific Project for China New Drug Discovery and Development during the Twelfth Five-Year Plan-preclinical study on suanzaoren granules [2014ZX09304306-007]
- Key Technologies of Common Quality Evaluation of New Drugs [2015010201]
- Liaoning Province Science and Technology Research Project [201610163L02]
- National Key Scientific Project for China New Drug Discovery and Development during the Twelfth Five-Year Plan-Technology re-innovation of generic and superstar drugs [2014ZX09201-002]
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Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, etc. Their basic structures consist of C-6-C-3-C-6 rings with different substitution patterns to produce a series of subclass compounds, and correlations between chemical structures and bioactivities have been studied before. Given their poor bioavailability, however, information about associations between structure and biological fate is limited and urgently needed. This review therefore attempts to bring some order into relationships between structure, activity as well as pharmacokinetics of bioactive flavonoids. (C) 2018 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.
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