Journal
REACTION CHEMISTRY & ENGINEERING
Volume 3, Issue 5, Pages 722-732Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8re00116b
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Funding
- Royal Society
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Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address with the aid of tubular flow systems and a simple heated rotating flow reactor. The prepared coumalate derivatives can be further used in inverse electron demand Diels-Alder reactions to synthesise compounds with many applications including molecular electronics, with the added advantage of providing metal-free preparations.
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