Journal
CELLS
Volume 7, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells7040024
Keywords
blood-brain barrier; drug delivery system to brain; central nervous system; diseases; permeability improvements
Categories
Funding
- Key Program of Hunan Provincial Department of Science and Technology [2016NK2096]
- China of Postdoctoral Science Foundation [2016M592456]
- Hunan Provincial Natural Science Foundation
- Hunan University of Technology
- Hunan Provincial philosophy and Social Science Foundation of China [16YBA129]
- Project of Science and Technology Department of Hunan Province
- Zhuzhou Science and Technology Plans [201707-201806]
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The blood-brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.
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