Journal
CANCERS
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cancers10060164
Keywords
3D cell culture; colorectal cancer; drug resistance; cancer stem cells
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Funding
- Japan Society for the Promotion of Science [17K15370]
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Colorectal cancer (CRC) is one of the most common cancers, for which combination treatment of chemotherapy is employed. However, most patients develop drug resistance during the course of treatment. To clarify the mechanisms of drug resistance, various research models have been developed. Recently, we established a human CRC patients-derived three-dimensional (3D) culture system using an air-liquid interface organoid method. It contained numerous cancer stem cells and showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce conventional and our established models for studying drug resistance in CRC.
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