Journal
CANCERS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cancers10040118
Keywords
polyploid/multinucleated giant cells; metastasis; anticancer treatment; cancer relapse
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Funding
- Canadian Breast Cancer Foundation-Prairies/North West Territories region
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Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated genomic content, often with multiple nuclei. The frequency of giant cells can increase markedly following anticancer treatment. Although giant cells enter a dormant phase and therefore do not form macroscopic colonies (aggregates of >= 50 cells) in the conventional in vitro colony formation assay, they remain viable and metabolically active. The purpose of this commentary is to underscore the potential importance of polyploid/multinucleated giant cells in metastasis and cancer recurrence following exposure to anticancer agents. We also discuss the possibility that most preclinical (cell-based and animal model) drug discovery approaches might not account for delayed responses that are associated with dormant giant cells.
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